The Difference between Frankincense and Myrrh

December 16, 2020

It's that time of year again, when holiday songs play 24/7 on the radio and people start wondering what, exactly, frankincense and myrrh are and why they make good gifts. LECO placed these two oils in a Pegasus® BT 4D to see the difference.

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Determining MOSH/MOAH with GCxGC-TOFMS

April 23, 2020

Contamination of food by mineral oil hydrocarbons such as mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) has been a growing concern since 2012, when the European Food Safety Authority flagged them as a potential health concern. While the main concerns are bioaccumulation from MOSH and the carcinogenicity of MOAH, data on consumer exposure is incomplete. Prevailing wisdom suggests we make every effort to minimize MOSH/MOAH contamination, however, MOSH/MOAH analysis is not easy. Though there is a standard European GC-FID method, countries are still discussing GC-MS standard methods for MOSH/MOAH analysis. The existing methods struggle to deconvolute the various hydrocarbons.

Enter the LECO Pegasus® BT 4D with GCxGC-TOFMS.

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Medical Investigation using Breath Analysis and GCxGC-TOFMS: Optimizing Data for Accurate Treatment

March 19, 2020

At our ASMS breakfast seminars, Jean-François (Jef) Focant, Head of the Department of Chemistry and Director of the Organic and Biological Analytical Chemistry group at the University of Liège, Belgium, spoke about using our Pegasus® BT 4D and Pegasus® GC-HRT 4D for GCxGC-TOFMS on the breath of asthma patients to improve asthma treatment*. Before diving into the blood and sputum, Jef first educated us on the importance of optimizing your data.

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Our Lab at Your Front Door

February 26, 2020

LECO understands that taking time away from your lab to visit our headquarters in Saint Joseph, Michigan, is not always a possibility. Travel alone is a hassle, much less the downtime of being away from your lab and the expense of all of the arrangements. Unfortunately, even our bench-top Pegasus® GC-TOFMS is a bit too large to slip into a carry-on for an in-person experience. Webinars and virtual demonstrations have come a long way in bringing new technology closer for your inspection, but there's nothing like getting to kick the tires and have a hands-on experience to really know what you could be adding to your lab. What’s a busy lab manager to do?

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ASMS in Review: Frank Dorman, Penn State

August 20, 2019

Frank Dorman, an Associate Professor of Biochemistry and Molecular Biology at Penn State University, spoke at our ASMS breakfast seminar about his experience using our Pegasus BT 4D benchtop GCxGC-TOFMS to analyze environmental contamination in the Susquehanna river. Due to the increasing chemical complexity of the environment, GCxGC-TOFMS with its Non-Targeted compound analysis is the ideal technology for these intricate samples.

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LECO Releases New Flow Modulator—FLUX™

January 23, 2019

LECO is pleased to introduce a new FLUX™ flow modulator option for routine GCxGC analysis. While LECO’s traditional thermal modulation alternative is still available and provides for the highest sensitivity, the FLUX flow modulator is a cost-effective option that makes GCxGC more accessible and easy to use.

The new flow modulator’s extraordinarily simple design is based on the principles of John Seeley et al. This straightforward design makes the flow modulator easy for the user to set up and start performing GCxGC analysis. The flow-based modulator is ideal for users who want to perform robust GCxGC analysis, but do not need the sensitivity of standard quad jet thermal modulation. Ideal samples are complex, but relatively concentrated. Our early users program has given us tremendously positive feedback.


Another advantage of the FLUX flow modulator is that it does not require cryogens to carry out GCxGC, saving the user time and resources in their lab. Method development is also simplified, as there are only two parameters for the user to manage; the flows are handled by software so the user does not have to set these themselves. The FLUX flow modulator is available for purchase with our Pegasus® BT 4D, and also for existing Pegasus BT owners who wish to upgrade their system to a GCxGC with FLUX.

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How GC-MS Can Solve the Puzzle of Metabolomics

November 14, 2018

Metabolomics presents challenges for both the analytical methods used and the data reduction required to interpret the results. No single analytical technique can be used for complete characterization of the metabolome, and no metabolome has ever been completely characterized. This is where GC-MS comes in...

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Why Limit Your Analysis with MS/MS?

June 6, 2018

In your application work, you need the power to analyze even the most complex samples. MS/MS can restrict your analysis due to its targeted nature, giving you “tunnel vision” and causing you to potentially miss key analytes. Our Pegasus BT 4D is the solution to coelution. You won’t limit your analysis with GCxGC-TOFMS as it provides the complete picture while also transforming your lab’s productivity. You’ll save time, improve your sample throughput, and increase confidence in your analyte identification, without missing a thing.

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Put GCxGC to Work in Your Lab with LECO at ISCC/GCxGC

May 2, 2018

Visit us at Booth #3
Stop by to see our NEW benchtop solution for GCxGC-MS analysis, the  Pegasus BT 4D . Talk with our GCxGC experts who will help  identify the right GCxGC tool for your application.

Schedule a software demo with our team of Application Experts, and discover how to make GCxGC part of your every-day analysis.
 
Vendor Seminar
GC×GC-(HR)TOFMS:
A Key Player in Your Tool Box for Medical Applications
Presented by Jean-François Focant, University of Liege
Tuesday, May 15th, 15:45-16:45 pm | Room 300
Register


GC×GC-(HR)TOFMS has reached maturity and can now be used to solve routine complex separation science issues. This is particularly true for several medical applications that require non-targeted screening of biological markers of interest either for population screening or better understanding of specific biological pathways. However, this increase of analytical resolution comes with an increase of system and data complexity, creating a critical need for adequate method optimization and quality control (QC) protocols. Learn more at our seminar, where examples of the use of thermal desorption (TD) and solid-phase microextraction (SPME) GC×GC-(HR)TOFMS will be highlighted in the field of respiratory diseases.

Register Today!

Oral Presentations
COMPREHENSIVE NON-TARGET CHARACTERIZATION OF EXPOSOME SAMPLES USING GCXGC AND HIGH RESOLUTION MASS SPECTROMETRY
Lorne Fell | LECO Corporation, United States | Monday, May 14th, 12:40 pm | Le.17

A GCXGC-TOFMS METHOD FOR THE QUANTIFICATION OF 54 ALLERGENS IN FRAGRANCE MATERIALS
Sebastiano Pantò | LECO European Application and Technology Center, Germany
Monday, May 14th, 17:10 pm | KNLe.05

A DIRECT COMPARISON OF THERMAL MODULATION AND TWO MODES OF FLOW MODULATION FOR GCXGC
David J. Borton | LECO Corporation, United States | Tuesday, May 15th, 14:20 pm | Le.34

Poster Presentations

Click here for a complete list of Poster Presentations at the event.

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Investigating Cannabis with GCxGC-TOFMS

April 23, 2018

Cannabis, and its use for medical or recreational purposes, has been a hot topic in both the political and social realms in recent years. From a medical standpoint, these chemicals may help treat a number of illness and symptoms, such as chronic pain, multiple sclerosis, epilepsy, anxiety, and cancer through ingestion, inhalation, or topical application. Cannabis is a complex mixture made up specifically of cannabinoids, terpenes, flavonoids, and other chemicals related to delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). The relationship between terpenes and cannabinoids, and how they work together to create a therapeutic experience is termed the “Entourage Effect”.

Analyzing the total composition of cannabis is an important aspect of determining its potency and medical effectiveness. The terpenes in its chemical makeup are what give cannabis its aromatic and flavor profile, and as True Terpenes describes, “It is the terpenes in cannabis which modulate (modify or control) the effect that the cannabinoids in each sample will have on the user, this is why strains of cannabis effect each user uniquely. For example, if you have 2 different types of cannabis and both have 15% THC, but one gives you energetic effects and one gives you sedative effects, this is largely due to the different terpene profiles.” Therefore, better understanding the chemical framework of cannabis can aid in determining how certain strains may work.

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