Food contamination by mineral oil hydrocarbons (MOH), which is usually separated into the subclasses of MOSH (Mineral Oil Saturated Hydrocarbons) and MOAH (Mineral Oil Aromatic Hydrocarbons), is a growing concern across the EU and the world. In 2012, the European Food Safety Authority flagged them as a potential health concern, and the increasing research since then has only been expanding our understanding of these hydrocarbons. However, the two main analytical methods suggested to quantify these substances, either an off-line method consisting of a solid phase extraction (SPE) followed by a GC-FID analysis or an on-line, LC-GC-FID method, both can result in inaccuracies and leads to challenges in the end results. Some of these inaccuracies are due to the lack of a strong and robust confirmatory method. However, a GCxGC-TOFMS system, like LECO's Pegasus® BT 4D can help unveil the complexity of contaminated food samples. It has also been suggested by the EFSA to be used as a confirmatory tool in case of uncertain results from other standard methods.

LECO has released a revolutionary new data analysis software for GCxGC data: ChromaTOF Tile. This software provides an industry-first data comparison tool that identifies statistically significant differences between classes of samples, reducing days-to- weeks of work down to hours, or even minutes. Based on Dr. Robert Synovec’s tile-based Fisher ratio analysis, ChromaTOF Tile partitions the data into a set of regions (tiles) and compares regionalized data. This allows it to disregard normal variances of alignment shifts to focus on where the actual differences are, so users can stop looking at their data and start actually using it.

Tomatoes are the second-most important vegetable crop in the world (arguments over whether or not it should be called a fruit or a vegetable aside!), and thus it is critically important that tomato yields are kept high. Pesticides are the easiest way to control populations that might destroy crops, but we must make sure that the resulting tomatoes are not contaminated. With GCxGC-TOFMS, recognizing and identifying pesticide residue in tomatoes is easier than ever.

It's that time of year again, when holiday songs play 24/7 on the radio and people start wondering what, exactly, frankincense and myrrh are and why they make good gifts. LECO placed these two oils in a Pegasus® BT 4D to see the difference.

Contamination of food by mineral oil hydrocarbons such as mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) has been a growing concern since 2012, when the European Food Safety Authority flagged them as a potential health concern. While the main concerns are bioaccumulation from MOSH and the carcinogenicity of MOAH, data on consumer exposure is incomplete. Prevailing wisdom suggests we make every effort to minimize MOSH/MOAH contamination, however, MOSH/MOAH analysis is not easy. Though there is a standard European GC-FID method, countries are still discussing GC-MS standard methods for MOSH/MOAH analysis. The existing methods struggle to deconvolute the various hydrocarbons.

Enter the LECO Pegasus® BT 4D with GCxGC-TOFMS.

At our ASMS breakfast seminars, Jean-François (Jef) Focant, Head of the Department of Chemistry and Director of the Organic and Biological Analytical Chemistry group at the University of Liège, Belgium, spoke about using our Pegasus^® BT 4D and Pegasus^® GC-HRT 4D for GCxGC-TOFMS on the breath of asthma patients to improve asthma treatment*. Before diving into the blood and sputum, Jef first educated us on the importance of optimizing your data.

LECO understands that taking time away from your lab to visit our headquarters in Saint Joseph, Michigan, is not always a possibility. Travel alone is a hassle, much less the downtime of being away from your lab and the expense of all of the arrangements. Unfortunately, even our bench-top Pegasus® GC-TOFMS is a bit too large to slip into a carry-on for an in-person experience. Webinars and virtual demonstrations have come a long way in bringing new technology closer for your inspection, but there's nothing like getting to kick the tires and have a hands-on experience to really know what you could be adding to your lab. What’s a busy lab manager to do?

Frank Dorman, an Associate Professor of Biochemistry and Molecular Biology at Penn State University, spoke at our ASMS breakfast seminar about his experience using our Pegasus BT 4D benchtop GCxGC-TOFMS to analyze environmental contamination in the Susquehanna river. Due to the increasing chemical complexity of the environment, GCxGC-TOFMS with its Non-Targeted compound analysis is the ideal technology for these intricate samples.

LECO is pleased to introduce a new FLUX™ flow modulator option for routine GCxGC analysis. While LECO’s traditional thermal modulation alternative is still available and provides for the highest sensitivity, the FLUX flow modulator is a cost-effective option that makes GCxGC more accessible and easy to use.

Another advantage of the FLUX flow modulator is that it does not require cryogens to carry out GCxGC, saving the user time and resources in their lab. Method development is also simplified, as there are only two parameters for the user to manage; the flows are handled by software so the user does not have to set these themselves. The FLUX flow modulator is available for purchase with our Pegasus^® BT 4D, and also for existing Pegasus BT owners who wish to upgrade their system to a GCxGC with FLUX.

Metabolomics presents challenges for both the analytical methods used and the data reduction required to interpret the results. No single analytical technique can be used for complete characterization of the metabolome, and no metabolome has ever been completely characterized. This is where GC-MS comes in...